RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.
Identifieur interne : 000510 ( Main/Exploration ); précédent : 000509; suivant : 000511RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.
Auteurs : Anne T. Schneider [Allemagne] ; Jérémie Gautheron [Allemagne] ; Maria Feoktistova [Allemagne] ; Christoph Roderburg [Allemagne] ; Sven H. Loosen [Allemagne] ; Sanchari Roy [Allemagne] ; Fabian Benz [Allemagne] ; Peter Schemmer [Allemagne] ; Markus W. Büchler [Allemagne] ; Ueli Nachbur [Australie] ; Ulf P. Neumann [Allemagne] ; Rene Tolba [Allemagne] ; Mark Luedde [Allemagne] ; Jessica Zucman-Rossi [France] ; Diana Panayotova-Dimitrova [Allemagne] ; Martin Leverkus [Allemagne] ; Christian Preisinger [Allemagne] ; Frank Tacke [Allemagne] ; Christian Trautwein [Allemagne] ; Thomas Longerich [Allemagne] ; Mihael Vucur [Allemagne] ; Tom Luedde [Allemagne]Source :
- Cancer cell [ 1878-3686 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Caspase 8 (métabolisme), Facteur de nécrose tumorale alpha (pharmacologie), Facteur de transcription NF-kappa B (physiologie), Facteur-2 associé aux récepteurs de TNF (physiologie), Humains, Hépatocytes (physiologie), Mâle, Proteasome endopeptidase complex (métabolisme), Receptor-Interacting Protein Serine-Threonine Kinases (physiologie), Souris, Souris de lignée C57BL, Tumeurs du foie (), Tumeurs du foie (étiologie).
- MESH :
- métabolisme : Caspase 8, Proteasome endopeptidase complex.
- pharmacologie : Facteur de nécrose tumorale alpha.
- physiologie : Facteur de transcription NF-kappa B, Facteur-2 associé aux récepteurs de TNF, Hépatocytes, Receptor-Interacting Protein Serine-Threonine Kinases.
- étiologie : Tumeurs du foie.
- Animaux, Humains, Mâle, Souris, Souris de lignée C57BL, Tumeurs du foie.
English descriptors
- KwdEn :
- Animals, Caspase 8 (metabolism), Hepatocytes (physiology), Humans, Liver Neoplasms (etiology), Liver Neoplasms (prevention & control), Male, Mice, Mice, Inbred C57BL, NF-kappa B (physiology), Proteasome Endopeptidase Complex (metabolism), Receptor-Interacting Protein Serine-Threonine Kinases (physiology), TNF Receptor-Associated Factor 2 (physiology), Tumor Necrosis Factor-alpha (pharmacology).
- MESH :
- chemical , metabolism : Caspase 8, Proteasome Endopeptidase Complex.
- etiology : Liver Neoplasms.
- chemical , pharmacology : Tumor Necrosis Factor-alpha.
- physiology : Hepatocytes, NF-kappa B, Receptor-Interacting Protein Serine-Threonine Kinases, TNF Receptor-Associated Factor 2.
- prevention & control : Liver Neoplasms.
- Animals, Humans, Male, Mice, Mice, Inbred C57BL.
Abstract
Receptor-interacting protein kinase 1 (RIPK1) represents an essential signaling node in cell death and inflammation. Ablation of Ripk1 in liver parenchymal cells (LPC) did not cause a spontaneous phenotype, but led to tumor necrosis factor (TNF)-dependent hepatocyte apoptosis and liver injury without affecting inducible nuclear factor κB (NF-κB) activation. Loss of Ripk1 induced the TNF-dependent proteasomal degradation of the E3-ligase, TNF receptor-associated factor 2 (TRAF2), in a kinase-independent manner, thereby activating caspase-8. Moreover, loss of both Ripk1 and Traf2 in LPC not only resulted in caspase-8 hyperactivation but also impaired NF-κB activation, promoting the spontaneous development of hepatocellular carcinoma. In line, low RIPK1 and TRAF2 expression in human HCCs was associated with an unfavorable prognosis, suggesting that RIPK1 collaborates with TRAF2 to inhibit murine and human hepatocarcinogenesis.
DOI: 10.1016/j.ccell.2016.11.009
PubMed: 28017612
Affiliations:
- Allemagne, Australie, France
- Bade-Wurtemberg, District de Cologne, District de Karlsruhe, Rhénanie-du-Nord-Westphalie, Schleswig-Holstein, Victoria (État), Île-de-France
- Aix-la-Chapelle, Heidelberg, Kiel, Melbourne, Paris
- Université de Melbourne
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Büchler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Nachbur, Ueli" sort="Nachbur, Ueli" uniqKey="Nachbur U" first="Ueli" last="Nachbur">Ueli Nachbur</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research and University of Melbourne, Parkville, VIC 3050/3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research and University of Melbourne, Parkville, VIC 3050/3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Neumann, Ulf P" sort="Neumann, Ulf P" uniqKey="Neumann U" first="Ulf P" last="Neumann">Ulf P. Neumann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Visceral and Transplantation Surgery, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Visceral and Transplantation Surgery, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Tolba, Rene" sort="Tolba, Rene" uniqKey="Tolba R" first="Rene" last="Tolba">Rene Tolba</name><affiliation wicri:level="3"><nlm:affiliation>Department of Laboratory Animal Research, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Laboratory Animal Research, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Luedde, Mark" sort="Luedde, Mark" uniqKey="Luedde M" first="Mark" last="Luedde">Mark Luedde</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Hospital, 24105 Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, University Hospital, 24105 Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Zucman Rossi, Jessica" sort="Zucman Rossi, Jessica" uniqKey="Zucman Rossi J" first="Jessica" last="Zucman-Rossi">Jessica Zucman-Rossi</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, UMR-1162, Functional Genomic of Solid Tumors, 75010 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR-1162, Functional Genomic of Solid Tumors, 75010 Paris</wicri:regionArea><wicri:noRegion>75010 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Panayotova Dimitrova, Diana" sort="Panayotova Dimitrova, Diana" uniqKey="Panayotova Dimitrova D" first="Diana" last="Panayotova-Dimitrova">Diana Panayotova-Dimitrova</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Leverkus, Martin" sort="Leverkus, Martin" uniqKey="Leverkus M" first="Martin" last="Leverkus">Martin Leverkus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Preisinger, Christian" sort="Preisinger, Christian" uniqKey="Preisinger C" first="Christian" last="Preisinger">Christian Preisinger</name><affiliation wicri:level="3"><nlm:affiliation>Proteomics Facility, IZKF, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Proteomics Facility, IZKF, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Tacke, Frank" sort="Tacke, Frank" uniqKey="Tacke F" first="Frank" last="Tacke">Frank Tacke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Trautwein, Christian" sort="Trautwein, Christian" uniqKey="Trautwein C" first="Christian" last="Trautwein">Christian Trautwein</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Longerich, Thomas" sort="Longerich, Thomas" uniqKey="Longerich T" first="Thomas" last="Longerich">Thomas Longerich</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Vucur, Mihael" sort="Vucur, Mihael" uniqKey="Vucur M" first="Mihael" last="Vucur">Mihael Vucur</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen, Germany. Electronic address: mvucur@ukaachen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Luedde, Tom" sort="Luedde, Tom" uniqKey="Luedde T" first="Tom" last="Luedde">Tom Luedde</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen, Germany. Electronic address: tluedde@ukaachen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28017612</idno><idno type="pmid">28017612</idno><idno type="doi">10.1016/j.ccell.2016.11.009</idno><idno type="wicri:Area/PubMed/Corpus">001238</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001238</idno><idno type="wicri:Area/PubMed/Curation">001227</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001227</idno><idno type="wicri:Area/PubMed/Checkpoint">001227</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001227</idno><idno type="wicri:Area/Ncbi/Merge">004086</idno><idno type="wicri:Area/Ncbi/Curation">004086</idno><idno type="wicri:Area/Ncbi/Checkpoint">004086</idno><idno type="wicri:Area/Main/Merge">000505</idno><idno type="wicri:Area/Main/Curation">000510</idno><idno type="wicri:Area/Main/Exploration">000510</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.</title><author><name sortKey="Schneider, Anne T" sort="Schneider, Anne T" uniqKey="Schneider A" first="Anne T" last="Schneider">Anne T. Schneider</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Gautheron, Jeremie" sort="Gautheron, Jeremie" uniqKey="Gautheron J" first="Jérémie" last="Gautheron">Jérémie Gautheron</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Feoktistova, Maria" sort="Feoktistova, Maria" uniqKey="Feoktistova M" first="Maria" last="Feoktistova">Maria Feoktistova</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Roderburg, Christoph" sort="Roderburg, Christoph" uniqKey="Roderburg C" first="Christoph" last="Roderburg">Christoph Roderburg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Loosen, Sven H" sort="Loosen, Sven H" uniqKey="Loosen S" first="Sven H" last="Loosen">Sven H. Loosen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Roy, Sanchari" sort="Roy, Sanchari" uniqKey="Roy S" first="Sanchari" last="Roy">Sanchari Roy</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Benz, Fabian" sort="Benz, Fabian" uniqKey="Benz F" first="Fabian" last="Benz">Fabian Benz</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Schemmer, Peter" sort="Schemmer, Peter" uniqKey="Schemmer P" first="Peter" last="Schemmer">Peter Schemmer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W" last="Büchler">Markus W. Büchler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Nachbur, Ueli" sort="Nachbur, Ueli" uniqKey="Nachbur U" first="Ueli" last="Nachbur">Ueli Nachbur</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research and University of Melbourne, Parkville, VIC 3050/3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research and University of Melbourne, Parkville, VIC 3050/3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Neumann, Ulf P" sort="Neumann, Ulf P" uniqKey="Neumann U" first="Ulf P" last="Neumann">Ulf P. Neumann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Visceral and Transplantation Surgery, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Visceral and Transplantation Surgery, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Tolba, Rene" sort="Tolba, Rene" uniqKey="Tolba R" first="Rene" last="Tolba">Rene Tolba</name><affiliation wicri:level="3"><nlm:affiliation>Department of Laboratory Animal Research, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Laboratory Animal Research, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Luedde, Mark" sort="Luedde, Mark" uniqKey="Luedde M" first="Mark" last="Luedde">Mark Luedde</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Hospital, 24105 Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, University Hospital, 24105 Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Zucman Rossi, Jessica" sort="Zucman Rossi, Jessica" uniqKey="Zucman Rossi J" first="Jessica" last="Zucman-Rossi">Jessica Zucman-Rossi</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, UMR-1162, Functional Genomic of Solid Tumors, 75010 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR-1162, Functional Genomic of Solid Tumors, 75010 Paris</wicri:regionArea><wicri:noRegion>75010 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Panayotova Dimitrova, Diana" sort="Panayotova Dimitrova, Diana" uniqKey="Panayotova Dimitrova D" first="Diana" last="Panayotova-Dimitrova">Diana Panayotova-Dimitrova</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Leverkus, Martin" sort="Leverkus, Martin" uniqKey="Leverkus M" first="Martin" last="Leverkus">Martin Leverkus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Preisinger, Christian" sort="Preisinger, Christian" uniqKey="Preisinger C" first="Christian" last="Preisinger">Christian Preisinger</name><affiliation wicri:level="3"><nlm:affiliation>Proteomics Facility, IZKF, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Proteomics Facility, IZKF, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Tacke, Frank" sort="Tacke, Frank" uniqKey="Tacke F" first="Frank" last="Tacke">Frank Tacke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Trautwein, Christian" sort="Trautwein, Christian" uniqKey="Trautwein C" first="Christian" last="Trautwein">Christian Trautwein</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Longerich, Thomas" sort="Longerich, Thomas" uniqKey="Longerich T" first="Thomas" last="Longerich">Thomas Longerich</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, RWTH Aachen University, 52074 Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Vucur, Mihael" sort="Vucur, Mihael" uniqKey="Vucur M" first="Mihael" last="Vucur">Mihael Vucur</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen, Germany. Electronic address: mvucur@ukaachen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Luedde, Tom" sort="Luedde, Tom" uniqKey="Luedde T" first="Tom" last="Luedde">Tom Luedde</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen, Germany. Electronic address: tluedde@ukaachen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany; Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, RWTH Aachen University, 52074 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author></analytic><series><title level="j">Cancer cell</title><idno type="eISSN">1878-3686</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Caspase 8 (metabolism)</term><term>Hepatocytes (physiology)</term><term>Humans</term><term>Liver Neoplasms (etiology)</term><term>Liver Neoplasms (prevention & control)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>NF-kappa B (physiology)</term><term>Proteasome Endopeptidase Complex (metabolism)</term><term>Receptor-Interacting Protein Serine-Threonine Kinases (physiology)</term><term>TNF Receptor-Associated Factor 2 (physiology)</term><term>Tumor Necrosis Factor-alpha (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Caspase 8 (métabolisme)</term><term>Facteur de nécrose tumorale alpha (pharmacologie)</term><term>Facteur de transcription NF-kappa B (physiologie)</term><term>Facteur-2 associé aux récepteurs de TNF (physiologie)</term><term>Humains</term><term>Hépatocytes (physiologie)</term><term>Mâle</term><term>Proteasome endopeptidase complex (métabolisme)</term><term>Receptor-Interacting Protein Serine-Threonine Kinases (physiologie)</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Tumeurs du foie ()</term><term>Tumeurs du foie (étiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Caspase 8</term><term>Proteasome Endopeptidase Complex</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Caspase 8</term><term>Proteasome endopeptidase complex</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Facteur de transcription NF-kappa B</term><term>Facteur-2 associé aux récepteurs de TNF</term><term>Hépatocytes</term><term>Receptor-Interacting Protein Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hepatocytes</term><term>NF-kappa B</term><term>Receptor-Interacting Protein Serine-Threonine Kinases</term><term>TNF Receptor-Associated Factor 2</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Tumeurs du foie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Receptor-interacting protein kinase 1 (RIPK1) represents an essential signaling node in cell death and inflammation. Ablation of Ripk1 in liver parenchymal cells (LPC) did not cause a spontaneous phenotype, but led to tumor necrosis factor (TNF)-dependent hepatocyte apoptosis and liver injury without affecting inducible nuclear factor κB (NF-κB) activation. Loss of Ripk1 induced the TNF-dependent proteasomal degradation of the E3-ligase, TNF receptor-associated factor 2 (TRAF2), in a kinase-independent manner, thereby activating caspase-8. Moreover, loss of both Ripk1 and Traf2 in LPC not only resulted in caspase-8 hyperactivation but also impaired NF-κB activation, promoting the spontaneous development of hepatocellular carcinoma. In line, low RIPK1 and TRAF2 expression in human HCCs was associated with an unfavorable prognosis, suggesting that RIPK1 collaborates with TRAF2 to inhibit murine and human hepatocarcinogenesis.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li></country><region><li>Bade-Wurtemberg</li><li>District de Cologne</li><li>District de Karlsruhe</li><li>Rhénanie-du-Nord-Westphalie</li><li>Schleswig-Holstein</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Aix-la-Chapelle</li><li>Heidelberg</li><li>Kiel</li><li>Melbourne</li><li>Paris</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Schneider, Anne T" sort="Schneider, Anne T" uniqKey="Schneider A" first="Anne T" last="Schneider">Anne T. Schneider</name></region><name sortKey="Benz, Fabian" sort="Benz, Fabian" uniqKey="Benz F" first="Fabian" last="Benz">Fabian Benz</name><name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W" last="Büchler">Markus W. Büchler</name><name sortKey="Feoktistova, Maria" sort="Feoktistova, Maria" uniqKey="Feoktistova M" first="Maria" last="Feoktistova">Maria Feoktistova</name><name sortKey="Gautheron, Jeremie" sort="Gautheron, Jeremie" uniqKey="Gautheron J" first="Jérémie" last="Gautheron">Jérémie Gautheron</name><name sortKey="Leverkus, Martin" sort="Leverkus, Martin" uniqKey="Leverkus M" first="Martin" last="Leverkus">Martin Leverkus</name><name sortKey="Longerich, Thomas" sort="Longerich, Thomas" uniqKey="Longerich T" first="Thomas" last="Longerich">Thomas Longerich</name><name sortKey="Loosen, Sven H" sort="Loosen, Sven H" uniqKey="Loosen S" first="Sven H" last="Loosen">Sven H. Loosen</name><name sortKey="Luedde, Mark" sort="Luedde, Mark" uniqKey="Luedde M" first="Mark" last="Luedde">Mark Luedde</name><name sortKey="Luedde, Tom" sort="Luedde, Tom" uniqKey="Luedde T" first="Tom" last="Luedde">Tom Luedde</name><name sortKey="Neumann, Ulf P" sort="Neumann, Ulf P" uniqKey="Neumann U" first="Ulf P" last="Neumann">Ulf P. Neumann</name><name sortKey="Panayotova Dimitrova, Diana" sort="Panayotova Dimitrova, Diana" uniqKey="Panayotova Dimitrova D" first="Diana" last="Panayotova-Dimitrova">Diana Panayotova-Dimitrova</name><name sortKey="Preisinger, Christian" sort="Preisinger, Christian" uniqKey="Preisinger C" first="Christian" last="Preisinger">Christian Preisinger</name><name sortKey="Roderburg, Christoph" sort="Roderburg, Christoph" uniqKey="Roderburg C" first="Christoph" last="Roderburg">Christoph Roderburg</name><name sortKey="Roy, Sanchari" sort="Roy, Sanchari" uniqKey="Roy S" first="Sanchari" last="Roy">Sanchari Roy</name><name sortKey="Schemmer, Peter" sort="Schemmer, Peter" uniqKey="Schemmer P" first="Peter" last="Schemmer">Peter Schemmer</name><name sortKey="Tacke, Frank" sort="Tacke, Frank" uniqKey="Tacke F" first="Frank" last="Tacke">Frank Tacke</name><name sortKey="Tolba, Rene" sort="Tolba, Rene" uniqKey="Tolba R" first="Rene" last="Tolba">Rene Tolba</name><name sortKey="Trautwein, Christian" sort="Trautwein, Christian" uniqKey="Trautwein C" first="Christian" last="Trautwein">Christian Trautwein</name><name sortKey="Vucur, Mihael" sort="Vucur, Mihael" uniqKey="Vucur M" first="Mihael" last="Vucur">Mihael Vucur</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Nachbur, Ueli" sort="Nachbur, Ueli" uniqKey="Nachbur U" first="Ueli" last="Nachbur">Ueli Nachbur</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Zucman Rossi, Jessica" sort="Zucman Rossi, Jessica" uniqKey="Zucman Rossi J" first="Jessica" last="Zucman-Rossi">Jessica Zucman-Rossi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.
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Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28017612" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |